PhD Oral Defense:Revealing the architecture of gene regulatory circuits in trypanosomatids
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PhD Oral Defense of听Vahid H Gazestani,听Institute of Parasitology
Trypanosomatid pathogens, causative agents of serious diseases in humans and animals, are听vector-borne parasites with intricate life cycle. These pathogens rely on fine regulation of 听gene听expression to respond and adapt to variable environments, with implications in transmission and听infectivity. Unlike mammals (hosts) or most other eukaryotes, trypanosomatid gene regulation听occurs at the post-transcriptional level mostly through interaction of trans-acting RNA-binding听proteins (RBPs) and cognate cis-acting sequence elements (卢RNA Regulatory Elements, RREs)听that direct mRNA maturation, localization, stability, and translation rate. However, these听regulatory elements and their mechanisms of actions are largely unknown. In this thesis, we use听integrated computational experimental strategies to unravel the regulatory circuits听controlling RNA processing and abundance in these human parasites that can be eventually听exploited to identify novel chemotherapeutics.
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