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John H. White, Ph.D. Professor Departments of Physiology and Medicine, 69热视频 McIntyre Medical Sciences Building, Room 1128 3655 Promenade Sir William Osler Montr茅al, Qu茅bec H3G 1Y6 Office phone:(514) 398-8498 john.white [at] mcgill.ca |
Research
Focus
There are three major projects in the laboratory.
(1) Molecular genetics of signaling by the nuclear vitamin D receptor and identification of vitamin D target genes implicated in (i) its capacity to stimulate innate immune responses, and (ii) its function as an anticancer agent.
(2) Chemical biology of vitamin D analogs. In collaboration with Dr. Jim Gleason in the Chemistry Department we are developing a series of bifunctional vitamin D analogs that combine agonism for the vitamin D receptor with inhibition of histone deacetylase activity.
(3) Characterization of novel factor identified in the lab called ligand-dependent corepressor (LCoR). LCoR was identified as a repressor of signaling by nuclear receptor transcription factors.
Keywords
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Selected Publications
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External Links
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